大炎肽与乳腺肿瘤恶化的关系

Association of Daintain Disease Progression in Breast Carcinomas

目的检测大炎肽在各类乳腺肿瘤组织中的分布,并验证它是否和乳腺肿瘤恶化相关。方法采用免疫组化辣根过氧化物酶染色检测。结果乳腺癌的阳性染色率为90%,良性肿瘤的阳性率为20.5%。和其他肿瘤相比,乳腺癌着色差异显著(P<0.005)。淋巴结转移癌中也有大炎肽分布。而良性组织中基本不表达。在乳腺癌样本中,大炎肽免疫着色强度随着组织增生、不典型增生和癌变的恶化而加深。结论大炎肽可能在乳腺肿瘤的恶化过程中起到了一定的作用。

Objective To investigate the spatial distribution of a new bioactive intestine peptide daintain in different kinds of breast tumours. Methods The expression of daintain in 66 cases was evaluated by immunohistocbemistry analysis. Results It has been found that there were significantly higher positive rate （90%） in breast cancer cases（ P〈0. 005）, the positive rate in benign turnouts is only 20. 5%. In addition, positive staining of daintain in lymphatic metastasis was clearly testified. No staining or weak staining was seen in benign tissues. Interestingly, the distribution of daintain among benign cells, hyperplasia tissues, immature hyperplasia and invasive breast cancer was distinct, and it presented the progression to the development of malignant lesion. Conclusion The fact mentioned above indicates that daintain is closely associated with disease progression in breast carcinomas.