联合检测胃液中CEA、CA199、CA242在胃癌诊断中的应用价值

Value of Combined Detection for CEA,CA199 and CA242 of Gastric Fluid in Diagnosis on Gastric Cancer

目的探讨胃液中CEA、CA199、CA242联合检测在胃癌早期诊断中的价值。方法采用化学发光和ELISA法测定28例胃癌、32例癌前疾病患者和28例对照者血清及胃液中CEA、CA199、CA242的含量。结果胃癌组胃液中CEA、CA199、CA242测定值平均水平和检测灵敏度显著性高于血清检测灵敏度(均P<0.01);胃癌组血清和胃液中CEA、CA199、CA242测定值平均水平显著高于癌前病变组和对照组(P<0.01);血清和胃液中三种肿瘤标志物联合检测的灵敏度显著提高(P<0.01)。结论胃液中CEA、CA199、CA242的联合监测,有助于胃癌的早期诊断和疗效追踪,有重要的临床应用价值。

Objective To evaluate the value of combined detection of CEA, CA199 and CA242 in gastric fluid in ailment diagnosis on gastric cancer. Methods The levels of CEA, CA199 and CA242 in serum and gastric fluid that gathered from 28 cases of gastric cancer and 32 cases of pre-cancer were analyzed by chemiluminescence immunoassay（CLIA） and enzyme linked lmmuno-sorbant assay（ELISA）, which control by 28 healthy, Results In the group of gastric cancer, the average levels and detecting sensitivity of CEA,CA199 and CA242 from gastric fluid were significantly higher than that of serum（P〈0. 01 ） ; There were also significant differences for the levels of these three indexes among the cancer, the pre-cancer and the control group, both in serum and in gastric fluid （P〈0. 01）; Combined detection of these three tumor markers has statistically enhanced diagnostic sensitivity（P〈0. 01 ）. Conclusion Combined detection for CEA ,CA199 and CA2.42, especially in gastric fluid, may play a role in both early diagnosis and supervision on therapeutic effects to gastric cancer.