阵发性孤立性房颤患者血浆B型钠利尿肽水平的研究

Clinical investigation of B-type natriuretic peptide in patients with paroxysmal lone atrial fibrillation

目的研究无器质性心脏疾患的房颤(AF)患者血浆B型钠利尿肽(BNP)水平。方法连续测定61例AF患者和61例年龄、性别相匹配的健康受试者的血浆BNP水平。结果AF组血浆BNP水平明显高于对照组(P<0.01)。多元回归分析结果显示,年龄、左房内径和AF病程是血浆BNP升高的独立预测因素(P<0.01)。结论阵发性孤立性AF患者BNP水平升高,其升高与AF直接相关但并非由左室功能障碍所致。

[ Objective] To investigate the levels of B-type natriuretic peptide （BNP） in patients with atrial fibrillation （AF） but no structural heart disease. [ Methods] Plasma BNP was measured in 61 consecutive AF patients and in 61 age- and gender-matched healthy subjects. [ Results ] Plasma BNP concentration in the AF group was significandy higher than in the control group （ 121 ±32 vs 41 ± 12 pg/ml, P 〈0. 01 ） . Multivariate regression analysis showed that age （r=0.66, P 〈0.01）, left atrial diameter （r=0.59, P〈0.01） and a history of AF （r=0.72, P〈0,01） were independent predictors of elevated BNP. [ Conclusion] BNP was elevated in patients with paroxysmal lone AF. The BNP elevation is directly related to AF but it does not appear to be the result of noticeable left ventricular dysfunction in these patients.