5Fonseca C,Simoes S,Gaspar R.Paclitaxel-loaded PLGA nanoparticles:preparation,physicochemical characterization and in vitro anti-tumoral activity[J].J Control Release,2002,83(2):273-286.
6Miyashita T,Reed JC.Tumor suooressor p53 is a direct transcriptional activator of the human Bax gene[J].Cell,1995;80(2):293-300.
7Rosse T,Olivier R,Monney L,et al.Bcl-2 prolongs cell survival after Bax-induced release of cytochrome C[J].Nature,1998;391(6666):496-9.
8Kitanaka C,Namiki T,Noguchi K,et al.Caspase-dependent pooptosis of cos-7 cells induced by Bax overexpression:differential effect of Bcl-2 and bcl-xl on Bax-induced caspase activation and apoptosis[J].Oncogene,1997;15(15):1763-72.
9Yang J,Liu X,Bhalla K,et al.Prevention of apoptosis by Bcl-2:release of cytochrome C from mitochondria blocked[J].Science,1997;275(5303):1129-32.
10Kluck RM,Bossy-wetzel E,Green DR,et al.The release of cytochrome C from mitochondria:a primary site for Bcl-2 regulxtion of apoptosis[J].Science,1997;275(5303):1132-6.