胃黏膜不典型增生患者血浆同型半胱氨酸和血清叶酸水平检测及叶酸补充治疗观察

Plasma Homocysteine and Serum Folate in Patients with Gastric Dysplasia and the Effect of Folate Supplement

目的:了解胃黏膜不典型增生患者血浆同型半胱氨酸(Hcy)与血清叶酸水平,并探讨其关系。方法:研究包括29例胃黏膜不典型增生患者和25例健康正常人,血浆Hcy的测定采用高效液相色谱荧光检测法,血清叶酸采用放射免疫方法测定。结果:胃黏膜不典型增生患者血浆Hcy水平显著高于正常对照组。胃黏膜不典型增生患者血清叶酸水平显著低于正常对照组。经叶酸补充治疗后,血浆Hcy显著降低,血清叶酸显著增高,胃黏膜不典型增生明显改善。结论:胃黏膜不典型增生患者血浆Hcy升高,而血清叶酸水平显著下降。血浆Hcy和血清叶酸水平可能是胃癌独立的危险因子,其关系值得进一步探讨。

Objective：To identify the plasma homocysteine and serum folic acid status in patients with gastric dysplasia and the effect of folate supplement. Methods ： 29 patients with gastric dysplasia and 25 healthy controls were studied and plasma homocysteine （Hcy） and serum folate were measured. Folate 5 mg/day,three months） were given for pa- tients with gastric dysplasia. Results： There was significant differences of the plasma Hcy level between patients with gastric dysplasia and healthy controls [（14.74±5.4） mol/L vs （8.16±3.5） mol/L,P〈0. 001]. There was also significant difference of the serum folate lavel between patients with gastric dysplasia and healthy controls [（4.29±3.13） ng/ ml vs （1l. 24±4.26） ng/ml,P〈0. 001]. The pathological examination indicated that gastric dysplasia improved after administration with folic acid supplement. Conclusion：There were close relationships between increased plasma Hcy and decreased serum folate levels and gastric dysplasia. Increased plasma Hcy and decreased serum folate may be the inde- pendent risk factors for gastric dysplasia. Folic acid supplement may be useful for reverse of gastric dysplasia. Further study is needed to clarify their relation.