肺炎衣原体与急性冠脉综合征关系的临床研究

Clinical Study of Relationship between Chlamydia Pneumoniae and Acute Coronary Syndrome

目的观察急性冠脉综合征患者肺炎衣原体感染情况,研究冠心病炎症与CPn感染的关系。方法99例疑诊"冠心病"收住兰州大学第一医院心内科患者,入院24h内清晨空腹静脉血标本留置,综合相关检查、治疗及病情转归情况确诊分为:ACS组48例(其中UAP组31例,AMI组17例),SAP组17例,非冠心病对照组13例;另门诊健康检查者30例经各相关检查后确定的10例健康者为健康对照组,用微量免疫荧光法测定血清中CPnlgG和lgM抗体滴度。结果各组实验对象CPnlgM抗体均为阴性。各组实验对象CPnlgG滴度值经Spearman等级相关分析(秩相关分析),相关系数无统计学意义(rs=0.175,P=0.102),说明各组lgG滴度与分组无关,分组与CPn慢性感染无关。结论本研究48例ACS,17例SAP均无CPn急性感染。各组CPn慢性感染率均高,本研究为断面研究、非动态研究,所选病人均是已发生ACS者,至于CPn与ACS启动在研究中未涉及。

Objective To evaluate CPn infection in patient with ACS and to investigate relationship between CPn infection and inflammation in CAD. Methods Seventy-eight patients were divided into ACS group （ 48 cases including 31 with UAP and 17 with AMI）, SAP group （17 cases）, non-CAD control group （ 13 cases ）; 10 cases healthy people as control group. IgG and IgM antibodies to CPn by MIF is analyzed in group respectively. Results IgM antibodies to CPn by MIF were negative in each group. That is to say, no any CPn acute infection was found in each group. According to Spearman statistic analysis （Bivarlate Correlations）, IgG antibodies to CPn by MIF revealed no statistical difference in each group （rs=0.178, P =0.102 ）. Conclusion No CPn acute infectionis found in each group. CPn chronic infection rate is high in each group.