AMACR在前列腺癌诊断与鉴别诊断中的应用
摘要
目的探讨α-甲基酰基-辅酶A消旋酶(AMACR)的表达在前列腺癌和良性前列腺增生病理诊断中的应用价值。方法采用免疫组织化学方法检测47例前列腺癌和29例良性前列腺增生组织标本中AMACR的表达。结果AMACR阳性表达在前列腺癌和良性前列腺增生两组间差异有显著性(P<0.01);前列腺癌Gleason评分分级与AMACR免疫表达无关。结论检测AM-ACR可提高前列腺癌诊断的准确率,对前列腺癌的病理诊断具有重要意义。
出处
《实用肿瘤学杂志》
CAS
2007年第4期342-343,共2页
Practical Oncology Journal
参考文献6
-
1Xu J,Stolk JA,Zhang X,et al.Identification of differentially expressed genes in human prostate cancer using subtraction and microarray[J].Cancer Res,2000; 60(6):1677-1682.
-
2Jiang Z,Woda BA,Rock KL,et al.p504s:a new molecular marker for the detection of prostate carcinoma[J].Am J surg Pathol,2001 ;25 (11):1397-1404.
-
3Luo J,Zha S,Gage WR,et al.Alpha-methylacyl-CoA racemase:a new molecular marker for prostate cancer[J].Cancer Res,2002; 62 (8):2220-2226.
-
4Rubin MA,Zhou M,Dhanasekaran SM,et al.Alpha-methylacyl coenzyme A racemase as a marker for prostate cancer[J].JAMA,2002; 287 (13):1662-1670.
-
5廖旭慧,赵碧芬,王维新,欧阳露.P504S、34βE12在前列腺癌诊断中的应用[J].临床医学,2006,26(1):65-66. 被引量：1
-
6Zhou M,chinnaiyan AM,Kleer CG,et al.Alpha-methylacyl-CoA racemase:a novel tumor marker over-expressed in sereial human cancers and their precursor leisions[J].Am J Surg Pathol,2002;26(7):926-931.
二级参考文献10
-
1Totton Rs, Heine mann MW, Hudson PB, et al. Microscopic differential diagnosis of latent carcinoma of the prostate, Arch Pathol, 1953,55 :131 -141.
-
2Xu J, stolk JA, zhang X, et al. Identification of differentially expressed genes in human prostate cancer using subtraction and microarter. Cancer Res ,2000,60 : 1677 - 1682.
-
3Luo J,Zha S, Gage WR, et al. Alpha - methylacy - Co A racemase : a new molecclar marker for pwstate cancer. Cancer Res, 2002, 62:2220 -2226.
-
4Rubin MA, Zhou M, Dhanasekaran SM, et al. Alpha - methylacyl coenzyme A racemase as a marker for prostate cancer. JAMA, 2002,287( 13 ) : 1662 -70.
-
5Lear I, Mcneal JE, Hosm, et al. Alpha - methylacyl - CoA race mase(P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transtition zone. Hum Pathol,2003,34(3) :228 - 223.
-
6Iczkowski KA,Jiang Z ,Tmtiakova M, et al, Prostatic needle biopsies with suspicious(ASAP) dingnosis:80% resolved using P504S/AMACR and kemtion 34βΕ12 immunostaining. Mod Pathol,2003,16 : 154A.
-
7Mills SE, Bostwick DG, Murphy WM, et al, Asymposium on the surgical pathology of the prostate, Pathol Annu, 1990,25 ( Pt2 ) : 109 - 158.
-
8Zhou M, Chinnaiyan AM, Kleer CG, et al. Alpha - Methylacyl - CoA racemase;a novel tumor marker over-expressed in sereral human cancers and their precursor lesions, Am J Sarg Pathol, 2002,26 ( 7 ) : 926 -931.
-
9Jiang Z,Wu CL,Woda BA,et al. P504S/Alpha-methylacyl -CoA racemase : a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol,2002,26:921-925.
-
10Jiang Z, Tretiakova M, Steinberg G, et al. Overexpression of Alpha -methylacyl-CoV radiation. Mod Pathol,2003,16:155A.
-
1刘强,朱建善,许燕萍,林鸿翔.胃腺癌组织α-甲基酰辅酶A消旋酶的表达[J].上海医学,2006,29(1):34-35.
-
2陆勤平,黄文斌,刘家祥,徐正.AMACR/p504S在胃癌中的表达及其临床意义[J].实用医学杂志,2012,28(16):2682-2684. 被引量：2
-
3沈红,王芳,程涛,陈俊.前列腺特异性膜抗原、α-甲基酰基辅酶A消旋酶在前列腺癌中的表达及其临床意义[J].昆明医科大学学报,2014,35(12):49-53.
-
4张军,刘湘国,谭永华.胃肠道间质瘤中E-cadherin和Ki-67的表达及临床意义[J].中国医药导报,2009,6(20):15-17. 被引量：3
-
5朱宁希,胡致平,虞荣喜,沈红强.急性髓系白血病淋系抗原的表达及其意义[J].上海免疫学杂志,1997,17(4):245-245. 被引量：1
-
6李立,刘铎.Caspase-3在口腔鳞状细胞癌中的表达及其预后意义[J].广州医药,2008,39(1):4-6.
-
7崔秀娟,李惠萍,洪生明,高长利.表皮生长因子受体在前列腺癌中的免疫表达和意义[J].中国医科大学学报,1996,25(4):355-356.
-
8李志鹏,李泽惠,刘志明.α-甲酰辅酶A消旋酶与胸腺素β_(15)对前列腺癌早期诊断的临床价值[J].医学综述,2012,18(6):919-921.
-
9马建华,白进良,傅梧.α-甲基酰基辅酶A消旋酶与前列腺癌的研究进展[J].国外医学（泌尿系统分册）,2004,24(5):599-601.
-
10许云飞,黄国华,鄢阳,张海民,巢月根,黄建华.膀胱肿瘤组织中AMACR的表达及意义[J].同济大学学报（医学版）,2006,27(4):24-26. 被引量：7
