流行性出血热血液流变学分析

Analysis of Hemorheology in Patients with Epidemic Hemorrhagic Fever

目的研究流行性出血热各期血流变的变化,探讨引起流行性出血热各期血流变变化的因素。方法测定30例流行性出血热各期全血黏度、血浆黏度、红细胞比容、红细胞聚集指数及TK值的变化并与30例健康人作对照。结果流行性出血热的发烧期、低血压休克期、多尿期的全血黏度、血浆黏度、红细胞聚集指数和TK值都增高(P<0.01);而少尿期的全血黏度、血浆黏度降低,但红细胞聚集指数及TK值也明显增高(P<0.01)。红细胞比容在发烧期正常,低血压期明显升高,少尿期降低,多尿期虽有回升,但仍显著低于正常。结论流行性出血热各期血流变明显异常;血流变异常是流行性出血热病理变化之一。

Objective To study the change of hemorhelogy in patients with epidemic hemorrhagic fever at all stages. Methods The hemorheological indexes such as whole blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index and TK index were measured in 30 cases with epidemic hemorrhagic fever and were compared with those of the normal controls. Results Whole blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index and TK index of the patient with epidemic hemorrhagic fever at fever stage and hypotension stage and polyuria stage were significantly higher than those of the normal control group. But whole blood viscosity, plasma viscosity of the patients with epidemic hemorrhagic fever at oliguria stage were lower than those of the normal control group. Conclusion Abnormal variation of hemorheology was one of the pathogeneses of the epidemic hemorrhagic fever.