唾液中滥用药物分析及其与血液中药物浓度的相关性

Analysis on The Abused Drugs in Saliva and Correlation of Saliva Drugs Concentrations with Blood Concentrations

唾液是一种成分简单、易于采集的体液,某些药物在唾液中的浓度可以反映其血药浓度。本文分析了滥用药物进入唾液的机制和影响因素,综述了唾液中滥用药物分析时样品的采集、前处理和检测方法以及唾液与血液中药物浓度的相关性。认为唾液是临床和法医学方面很有价值的分析样品,用唾液中滥用药物浓度来推测血药浓度具有一定的法医学意义。

Saliva is an easily collected body fluid and has simple composition. Some drugs concentrations in saliva can reflect their blood level. This paper analyzes the mechanisms of drug transfer from blood into saliva and the influencing factors, reviews the methods of sample collection, preparation, analysis of the abused drugs in saliva, and the relationship between abused drugs content in saliva and in blood. We believe that saliva is a valuable sample in clinic and forensic medicine. It is important in forensic science field to estimate abused drugs concentrations in blood by via their saliva concentrations.