4Vivona S, Gardy J L, Ramachandran S, et al. Computer-aided bio- technology: from immuno-informatics to reverse vaccinology [ J ]. Trends in Biotechnology, 2007, 26 (4) : 90-200.
5Davies M N, Flower D R. Harnessing bioinformatics to discover new vaccine [ J]. Drug Discovery Today, 12(9-10) : 389-395.
6Mora M, Veggi D, Santini L, et al. Reverse vaccinology [J]. Drug Discover Today, 2003, 10 (8) : 459-464.
7Xiang Z S, He Y Q. Vaxign: a web-based vaccine target design pro- gram for reverse vaccinology [ J]. Procedia in Vaccinology, 2009, 1 ( 1 ) : 23-29.
8Liang X, Teng A, Braun D M, merase chain reaction (TAP) : sing genome sequence data [ J ] ( 5 ) : 3593-3598. et al. Transcriptionally active poly- high throughput gene expression u- Gene Therapy Systems, 2002, 277.
9Seib K L, Oriente F, Adu-Bobie J, et al. Influence of seroproup B meningococcal vaccine antigen on growth and survival of the menin- gocoeeus in vitro and in ex vivo and in vivo models of infection [J]. Vaccine, 2010, 28(12): 2416-2427.
10Pizza M, Scarlato V, Masignani V, et al. Identification of vaccine candidates against serogroup B meningococcus by whole-genome se- quencing [J]. Science, 2000, 287(5459) : 1816-1820.