摘要
目的通过检测不同类型冠心病组及对照组外周血糖化血清蛋白(GSP)水平,以明确其与冠脉综合征(ACS)不稳定斑块的相关关系,探讨GSP在ACS中的可能机制。方法用硝基四氮唑蓝(NBT)显色法分别测定27例急性心肌梗死(AMI)、20例不稳定型心绞痛(UAP)、19例稳定型心绞痛(SAP)及20名非冠心病者(对照组)血中GSP的水平。结果GSP水平在ACS患者明显高于SAP及对照组(P<0.01);与肌酸磷酸激酶同工酶(CK-MB)、肌钙蛋白Ⅰ(cTnI)无明显相关性(P>0.05)。结论GSP水平升高与ACS斑块的不稳定性有关,但其水平的升高与心肌坏死无关。
Objective To measure peripheral blood glycated serum protein （GSP） in different patients with and without coronary disease to explore its relation with atherosclerotic instable plaques and the possible mechanism in acute coronary syndrome （ACS）. Method Circulating levels of GSP in 27 patients with acute myocardial infarction,20 with unstable angina, 19 with stable angina and 20 controls were measured by NBT color. Results Circulating GSP levels were significantly higer in patients with ACS than in patients with stable angina and controls （P 〈 0.01 ） ; but no correlation with CK-MB or cTnⅠ levels was observed （P 〉 0.05 ）. Conclusion The higher GSP level is a maker of instable plaque, but it is not generated in response to myocardial necrosis.
出处
《现代医学》
2007年第1期1-3,共3页
Modern Medical Journal
