卵巢肿瘤患者凝血及纤溶分子标志物变化

A clinical study on the change of coagulation and fibernolytic molecular markers in the patients with ovarian tumor

目的：探讨卵巢肿瘤患者凝血及纤溶分子标志物的变化情况。方法：选择2004年1月-2006年1月于我院妇科住院治疗的卵巢肿瘤患者122例为研究对象，并选择30例健康志愿者为正常对照组。所有对象均采血测定u-PA、u-PAR、PAP、TF、TFPI、TAT，病例组于治疗前后各测定一次。结果：①正常对照组与良性肿瘤组间各指标差异无统计学意义；浆液性囊腺癌组、黏液性囊腺癌组、恶性宫内膜样癌组u—PA、u—PAR、PAP、TF、TAT均高于正常对照组和良性肿瘤组（P〈0．05），但TFPI在各组间差别无统计学意义。②在每一组织类型的肿瘤中，分化程度越低，u-PA、u-PAR越高。③恶性卵巢肿瘤组u—PA、u—PAR、PAP、TF、TAT治疗后均有所下降（P〈0．05），但均未达正常对照水平。结论：恶性卵巢肿瘤患者存在着明显的止凝血功能紊乱。

Objective：To study the change of coagulation and fibernolytic molecular markers in the patients who suffered from ovarian tumor. Methods：One hundred and twenty two patients with ovarian tumor were studied, who were treated in the gynecology of our hospital during January 2004 to January 2006, compared with 30 volunteers as healthy subjects. The concentration of u-PA, u-PAR, PAP, TF, TFPI, TAT in blood were tested. Those parameters of the patients were tested before treatment and after treatment respectively. Results. （ 1 ） There was no statistical differences of every parameter between normal control group and group of benign tumor; the concentrations of u-PA, u-PAR, PAP, TF, TAT of every malignant tumor group were higher than those of normal control group and group of benign tumor（P 〈 0.05 ）. （2）In every malignant tumor group, the more rudimentary of the tumor cell, the higher of the concentration of u-PA, u-PAR. （3）After treatment, the concentration of u-PA, u- PAR, PAP, TF, TAT of every malignant tumor group decreased （P 〈 0.05 ）. Conclusion： There is dysfunction of coagulation and fibernolysis in the patients who suffered from ovarian tumor.