猪胆溶纤汤对肝纤维化大鼠血生化指标的影响

EFFECTS OF ZHUDAN-RONGXIAN SOUP ON BIOCHEMICAL INDICATORS IN SERUM OF HEPATIC FIBROSIS RATS

目的:观察猪胆溶纤汤(ZRS)对肝纤维化的预防和治疗作用。方法:采用四氯化碳皮下注射法建立大鼠肝纤维化模型,将肝纤维化大鼠随机分为预防组和治疗组,分别于造模同时和造模后灌胃给予ZRS (2ml/100g,1次/日,连续7周),观察ZRS对各组大鼠血生化指标、肝指数、脾指数的影响。结暴:ZRS预防组血清GPT、LDH水平与模型比较明显降低(P<0.05,P<0.01),ZRS预防组血清TP、A/G水平与模型比较显著升高(P<0.01),ZRS预防组肝指数与模型组比较显著升高(P<0.01)、脾指数显著降低(P<0.01)。ZRS治疗组血清GOT水平、脾指数与模型组比较明显降低(P<0.05)。结论:ZRS对四氯化碳所致大鼠肝纤维化具有预防和治疗作用。

Objeetive：To study the preventative and therapeutic effects of traditional Chinese medicine ZhudanRongxian Soup （ZRS） on hepatic fibrosis.Methods：The hepatic fibrosis rats model was established by subcutaneous injection of carbon tetrachloride.The hepatic fibrosis rats model were randomly divided into preventative group and therapeutic group.The rats in each group were respectively lavaged with ZRS （2ml/100g/d, 7 weeks） at the same time of establishing model or after the model was successfully established.The biochemical indicators in serum, the hepatic index, splenic index were detected.Results：GPT and LDH in serum of rats in ZRS preventative group were obviously lower than that of model group （P 〈 0.05,P 〈 0.01）;TP and A/G in serum of rats in ZRS preventative group were obviously higher than that of model group （P 〈 0.01）;The hepatic index was obviously higher and splenic index was obviously lower in ZRS preventative group compared with model group （P 〈 0.01）.GOT in serum of rats in ZRS therapeutic group was significantly lower than that of model group（P 〈 0.01）;The splenic index was obviously lower in ZRS therapeutic group compared with model group （P 〈 0.01）.Conclusions：Traditional Chinese medicine ZRS has preventative and therapeutic effects on hepatic fibrosis induced by carbon tetrachloride.