期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胰岛素受体底物-2基因多态性在多囊卵巢综合征中的初步研究

下载PDF
导出
摘要 目的:探讨多囊卵巢综合征(PCOS)患者与对照组胰岛素受体底物-2(IRS-2)基因密码子1057甘氨酸/天冬氨酸(1057Gly/Asp)多态性的不同。方法:应用PCR酶切方法(PCR-RFLP)检测60例PCOS患者和30例对照的IRS-2基因密码子1057G/A的等位基因分布及基因频率。结果:IRS-2基因型分布及基因频率在两组间差异有显著性,两组间空腹胰岛素、胰岛素抵抗指数(HOMA1-IR)、促黄体生成素/促卵泡刺激素(LH/FSH)、游离睾酮(T)的差异也有显著性。结论:IRS-2基因1057G/A多态性在PCOS患者和对照组之间差异有显著性,可能是PCOS患者发生胰岛素抵抗(IR)的机制之一,也可能是PCOS的易感基因。
作者 陈新华 任慕兰 丁昌平
机构地区 东南大学临床医学院 江苏省扬州市第一人民医院
出处 《中国民康医学》 2007年第16期612-613,646,共3页 Medical Journal of Chinese People’s Health
关键词 多囊卵巢综合征 胰岛素抗药性 胰岛素受体底物-2 多态现象(遗传学)
分类号 R771.75 [医药卫生—眼科] R588 [医药卫生—内分泌]
  • 相关文献

参考文献13

  • 1Solomn CG.The epidemiology of polycystic ovary syndrome.Prevalance and associated disease risks[J].Endocrinol Metab Clin North Am,1999,28:247-263.
  • 2Marsden PJ,Murdoch AP,Taylor R.Tissue insulin sensitivety and body weigh in polycystic ovary syndrome[J].Clin Endocrinol Metab,2001,55(2):191-199.
  • 3Ciampelli M,Leoni F,Lattanzi F,et al.A pilot study of the longterm effects of acipimox inpolycystic ovary syndrome[J].Hum Reprod,2002,17:647-653.
  • 4Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on diagnostic criteria and long-term health risks to polycystic ovary syndrome[J].Hum Reprod,2004,19(1):41-47.
  • 5Wallace TM,Levy JC,Matthews DR.Use and abuse of HOMA Modeling[J].Diabetes Care,2004,27:1487-1495.
  • 6Araki E,Lipes AM,Patti M,et al.Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene[J].nature,1994,372:186-189.
  • 7Pessin JE,Saltiel AR.Signaling pathways in insulin action:molecular targets of insulin resistance[J].Clin Invest,2000,106:165-169.
  • 8Vaben L,Wegrzyn W,Klein-Hitpass L.Human insulin receptor substrate-2(IRS-2) is a primary progesterone response gene[J].Mol Endocrinology,1999,13(3):485-494.
  • 9Domimic JW,Julio SG,Heather T,et al.Disruption of IRS-2 cause type 2 diabetes in mice[J].Nature,1998,391:900-904.
  • 10Leibiger IB,Leibiger B,Moede T,et al.Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/P70S6 kinase and CaM kinase pathways[J].Mol cell,1998,1:933-938.

二级参考文献13

  • 1Domimic J W,Julio S G,Heather T,et al.Disruption of IRS -2 causes type 2 diabetes in mice [J].Nature,1998,391:900-904.
  • 2Sun X J, Wang L M,Zhang Y T,et al.Role of IRS-2 in insulin and cytokine signalling [J].Nature,1995,377:173-177.
  • 3Lothar V,Wojciech W,Ludger K H,et al.Human insulin receptor su bstrate-2 gene organization and promoter characterization [J].Diabetes,1999,4 8:1877-1880.
  • 4Jens C B,Jonathon W,Bentley C,et al.Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells [J ].Mol Cellul Biol,1997,17:1513-1521.
  • 5Mary-Elizabeth P,Sun X J,Jens C B,et al.4PS/Insulin rece ptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice [J].J Biol Chem,1995,270:24670-24673.
  • 6Fasshauer M,Klein J,Ueki K,et al.Essential of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake i n brown adipocytes [J].J Biol Chem,2000,275:25494-25501.
  • 7Vassen L,Wegrzyn W,Klein-Hitpass L.Human insulin receptor sub strate-2 (IRS-2) is a primary progesterone response gene [J].Mol Endocrinol, 1999,13:485-494.
  • 8Valverde A M,Kahn C R,Benito M.Insulin signaling in insulin r eceptor substrate (IRS)-1-deficient brown adipocytes:requirement of IRS-1 for lipid synthesis [J].Diabetes,1999,48:2122-2131.
  • 9Joseph A.A signal for β-cell failure [J].Nature,1998,391:8 46-847.
  • 10Gazdag A C,Dumke C L,Kahn C R,et al.Calorie restriction increases insuli n-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice [J ].Diabetes,1999,48:1930-1936.

共引文献7

中国民康医学
2007年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部