糖尿病周围神经病变与氧化应激关系的研究现状

Exploration on the Relationship between Diabetic Peripheral Neuropathy and Oxidative Stress

糖尿病周围神经病变的发病机制尚未完全阐明,存在多个假说,氧化应激反应渗透于糖基化终产物形成、多元醇代谢、蛋白激酶C途径激活、微血管病变等不同假说之中。本文就氧化应激对糖尿病周围神经病变的影响和中西医治疗现况进行综述。

The pathogenesis of diabetic peripheral neuropathy （DPN） is not illustrated clearly nowadays, and there are several hypotheses. Oxidative stress response is penetrated in several different hypotheses as the formation of advanced glycosylation end products, polyhydric alcohol metabolic pathway, protein kinase C activation and microvascular lesion, etc. The influence of oxidative stress on DPN and the current status of anti-oxidation therapy by using integrative traditional and Western medicine were reviewed in this paper.