期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Nod2与克罗恩病相关性研究的进展 被引量：2

A dvances in research on the association of N od2 and C rohn d isease
下载PDF
导出
摘要 Nod2(Card15)及其相关的Nod1(Card4)都属于近年来研究较多的Nod分子家族。Nod蛋白最初被描述为细胞内Caspase和核因子-κB(NF-κB)信号转导通路的活化因子。随着分子生物学和遗传学研究的深入,NOD2(CARD15)基因与克罗恩病(CD)易患体质的关系逐渐明确。与此同时,生物化学研究证实Nod1及Nod2是细菌肽聚糖成分的细胞内识别分子。作者就Nod蛋白介导的细胞内细菌识别与CD的相关性研究作一综述。 Nod2（Cardl5） and its associated Nodl （Card4） belong to the Nod molecular family which has been widely researched in recent years. Nod proteins were initially described as activating factors within the intracellular Caspase and NF-KB signal transduction pathways. With the improvements of Molecular Biology and Genetics, the association of NOD2 （ CARD15 ） gene and the susceptibility of Crohn disease（CD） is becoming more and more legible. While, biochemical studies have revealed that Nodl and Nod2 can recognize different fragments of peptidoglycan respectively. This review focuses on recent insights into the Nods-mediated intracellular bacteria detection and the association of Nod2 and CD.
作者 倪海键 张新华
机构地区 南京大学医学院临床学院(南京军区南京总医院)病理科
出处 《医学研究生学报》 CAS 2007年第8期878-881,共4页 Journal of Medical Postgraduates
基金 南京军区南京总医院科研基金资助项目(批准号:2005111)
关键词 Nod2蛋白 NOD2(CARD15)基因 细胞内模式识别 克罗恩病 Nod2 protein NOD2 （ CARD15 ） gene Intracellularpattem-recognition Crohndisease
分类号 R574.62 [医药卫生—消化系统]
  • 相关文献

参考文献33

  • 1Beutler B,Rietschel ET.Innate immune sensing and its roots:the story of endotoxin[J].Nat Rev Immunol,2003,3(2):169-176.
  • 2Medzhitov R.Toll-like receptors and innate immunity[J].Nat Rev Immunol,2001,1:135-145.
  • 3Chamaillard M,Girardin SE,Viala J,et al.Nods,Nalps and Naip:intracellular regulators of bacterial-induced inflammation[J].Cell Micro,2003,5(9):581-592.
  • 4Inohara N,Nunez G.NODs:intracellular proteins involved in inflammation and apoptosis[J].Nat Rev Immunol,2003,3(5):371-382.
  • 5Inohara N,Koseki T,del Peso L,et al.Nod1,an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB[J].J Biol Chem,1999,274(21):14560-14568.
  • 6Hugot JP,Laurent-Puig P,Gower-Rousseau C,et al.Mapping of a susceptibility locus for Crohn's disease on chromosome 16[J].Nature,1996,379(6568):821-823.
  • 7Lesage S,Zouali H,Cézard JP,et al.CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease[J].Am J Hum Genet,2002,70(4):845-857.
  • 8Tanabe T,Chamaillard M,Ogura Y,et al.Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition[J].EMBO J,2004,23(7):1587-1597.
  • 9Yamazaki K,Takazoe M,Tanaka T,et al.Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease[J].J Hum Genet,2002,47(9):469-472.
  • 10Bonen DK,Nicolae DL,Moran T,et al.Racial differences in Nod2 variation:characterisation of Nod2 in African-Americans with Crohn disease[J].Gastroenterology,2002,122(Suppl):A29.

二级参考文献23

  • 1李光玉,白雪帆,杨为松.汉坦病毒核衣壳蛋白血清学分型研究进展[J].医学研究生学报,2004,17(9):839-842. 被引量：2
  • 2Sandborn WJ.Serologic markers in inflammatory bowel disease:state of the art[J].Rev Gastroenterol Disord,2004,4 (4):167-174.
  • 3Beaven SW,Abreu MT.Biomarkers in inflammatory bowel disease[J].Curr Opin Gastroenterol,2004,20(4):318-327.
  • 4Savige J,Nassis L,Cooper T,et al.ANCA-associated systemic vasculitis after immunization with bacterial proteins[J].Clin Exp Rheumatol,2002,20(6):783-788.
  • 5Eggena M,Cohavy O,Parseghian MH,et al.Identification of histone H1 as a cognate antigen of the ulcerative colitiss-associated marker antibody pANCA[J].J Autoimmun,2000,14(1):83-97.
  • 6Sobajima J,Ozaki S,Uesugi H,et al.High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis[J].Gut,1999,44 (6):867-873.
  • 7Lombardi G,Annese V,Piepoli A,et al.Antineutrophil cytoplasmic antibodies in inflammatory bowel disease:clinical role and review of the literature[J].Dis Colon Rectum,2000,43 (7):999-1007.
  • 8Ruemmele FM,Targan SR,Levy G,et al.Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease[J].Gastroenterology,1998,115 (4):822-829.
  • 9Sendid B,Quinton JF,Charrier G,et al.Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn's disease[J].Am Gastroentrol,1998,93 (8):1306-1310.
  • 10Shanahan F.Inflammatory bowel disease:immunodiagnostics,immunotherapeutics,and ecotherapeutics[J].Gastroenterology,2001,120(3):622-635.

共引文献5

同被引文献44

引证文献2

二级引证文献18

医学研究生学报
2007年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部