卡维地洛治疗慢性充血性心力衰竭57例疗效观察

Clin Ical Effects of Carvedilol on Patients with Chronic Congestive Heart Fallure

目的观察卡维地洛治疗慢性充血性心力衰竭(CHF)的疗效。方法将112例CHF病人随机分为治疗组(57例)和对照组(55例),对照组应用利尿剂、血管紧张素转换酶抑制剂(ACEI)、洋地黄类、硝酸酯类等治疗;治疗组在对照组治疗基础上应用卡维地洛,起始剂量为3.125 mg,1次/d,口服,1周后剂量加倍,最大剂量为12.5 mg,2次/d,6个月后进行疗效比较。结果卡维地洛治疗组患者的心功能、心率、左室射血分数(LVEF)、左室舒张末内径(LVEDD),6 min步行距离与对照组相比,均有显著性差异(P<0.01)。结论CHF患者在应用利尿剂、ACEI和洋地黄类治疗的基础上加用卡维地洛可取得更好的疗效,可明显改善心功能和运动耐量。

Objective To investigate the clinical effect of Carvedilol on patientswith Congestive HearFail- ure （CHF）. Methods 112 atients with CHF were randomly divided into Carvedilol observational group and control group. All the 112 patitnets were given angiotensin converting enzyme inhibitor （ACEI）, diuretics, digitalis and nitricacid ester. Carvedilol was taken orally in observationalgroup in addition. Initial dosage was 3. 125 rag,once perday. One week later, the dosagewas doubled with maximum of 12.5 rng ＆ twice per day.The curative effect was observed after a period of six - month treatment. Results There were significant differences in the improvement of cardiac function, heart rate, leftventricle ejection fraction （LVEF）, 6minute walking test, in observational group as compared with control group （ P 〈 0.01）. Concluion Better curative effectwillbe achieved on CHF patientswho take Carvedilol in addition than those who only take （ACEI）,diuretics ＆ digitalis,It could improve cardiac function and long-term outcome.