曲安奈德在玻璃体切割手术中的标记作用

The Demarcation Effect of Triamcinolone acetonide on Vitrectomy

目的探讨曲安奈德在玻璃体切割手术中标记残余玻璃体,玻璃体后皮质及视网膜前膜的作用,以及同对照组相比较术后眼压及视力是否有统计学意义。方法2004-06～2005-06,行玻璃体切割术患者78例78眼,分为治疗组术中玻璃体腔内注入TA。对视网膜表面残留玻璃体,玻璃体后皮质及视网膜前膜彻底清除。对照组未用TA。术后平均随访6个月,两组在视力及眼压方面进行对比分析。结果对照组术后2个月眼压:≥21 mmHg分别是13%和11%,无统计学意义;两组手术前后视力的变化无统计学意义。未见明显与药物相关的并发症。结论曲安奈德可以清晰标记残余玻璃体,玻璃体后皮质及视网膜前膜,有利于手术中辨认和清除,提高手术安全性及成功率,同时未见明显不良反应。

Objective To discuss the effect of TA which can demarcate the residue vitreous, post- vitreous cortex, preretinal membrane on vitrectomy and whether there are evident differences on post - operative IOP and visual acuity compare with comparison group. Methods From June 2004 to June 2005,78 cases （78eyes） were performed vitrectomy and were divided into study group and control group which contain 39 eyes respectively. We injected TA 0.5 mL into vitreous cavity of study group during the surgery. TA can demarcate the residue vitreous body sticking to the retinal surface, post -vitreous cortex, preretinal membrane and help to peel them off completely. TA was not used in the eyes of control group. The mean follow- up was 6 months after operation, visual acuity and IOP of the two groups were compared and analyzed. Results in study group and control group the incidence rate of higher IOP （21 mmHg） in two months after operation was 13 % and 11% respectively, no evident differences in comparison （ P 〉 0.05）. There was neither difference in visual acuity before and after operation nor obvious ocular complication related to TA. Conclusion TA can demarcate the residue vitreous, post- vitreous cortex and preretinal membrane clearly and made it discernible and easy to be peeled off completely which can improve the safety and success rate of surgery, no obvious side effects occurred.