加兰他敏对阿尔茨海默病大鼠认知功能的影响

The Effect of Galantamin on the Cognitive Function of Rats with Alzheimer's Disease

目的:研究加兰他敏对阿尔茨海默病大鼠认知功能的影响。方法:雄性SD大鼠35只,随机分为假手术组(10只)、链脲菌素(STZ)组(10只),加兰他敏组(15只)。侧脑室注射STZ制备阿尔茨海默病大鼠模型,水迷宫试验测定大鼠的学习记忆能力。加兰他敏3mg/kg,共6周。结果:术前三个组之间潜伏期及过平台次数无明显差异,术后第10天加兰他敏组潜伏期为48.64±8.41s,过平台次数为0.74±0.40,与STZ组比较,差异无统计学意义。治疗6周后加兰他敏组潜伏期为26.33±9.51s,过平台次数为3.33±1.51,与STZ组比较,差异有显著统计学意义。结论:加兰他敏对阿尔茨海默病大鼠的认知功能具有明显的改善作用。

Objective： To study the effect of galantamin on the cognitive function of the rats with Alzheimer＇s disease. Methods： 35 male SD rats were randomly divided into sham operated group （n=10）, streptozotocin （STZ） group （n=10）, and galantamin（GT） group （n=15）. The models of Alzheimer＇s disease were created by intracerebroventricular injection of streptozotocin, and a Morris maze was used to test the rats＇ learning and memory ability, GT （3mg/kg） was administered for six weeks. Results： There were no statistic differences among the three groups in the latent period and the times of passing through the platform before operation.Ten days after the operation, the latent period and passing through platform times of GT group were 48.64 ± 8,41 seconds and 0.74 ± 0.40, respectively, there was no statistic difference compared with the STZ group, Six weeks later, the latent period and passing through platform times of GT group were 26.33 ± 9.51 seconds and 3.33 ± 1.51, respectively, which had statistic differences compared with the STZ group. Conclusion： Galantamin could improve the learning and memory ability of rats with Alzheimer＇ s disease.