胸腺肽防治儿童反复呼吸道感染临床疗效观察

A clinical observation of therapeutic effect of thymopeptidum enteric-coated tablets for children with recurrent respiratory infection

目的 探讨迪赛胸腺肽肠溶片防治儿童反复呼吸道感染的临床疗效.方法 对我院2003年9月～2006年9月在幼儿园确诊有反复呼吸道感染病史的98名儿童,年龄3～5岁,征得家长同意随机抽取50例作为观察组,其余48例为对照组,观察组在常规治疗的基础上加服＂迪赛胸腺肽肠溶片＂,5mg,每时日1次,3个月为1个疗程.对照组采用常规治疗.以上幼儿均按体弱儿进行登记、管理、每月随访,每半年评价1次,连续观察1年以上.结果 观察组总有效率明显高于对照组,分别为92.0%和66.7%（P＜0.01）,差异有显著性.观察组病情得到控制人数及控制率明显高于对照组,分别为25人（50.0%）和10人（20.8%）,P＜0.01,差异有显著性意义.结论 迪赛胸腺肽肠溶片防治儿童反复呼吸道感染,疗效显著,未发现明显不良反应,易被儿童接受,值得推广使用.

Objective To observe therapeutic effect of thymopeptidum enteric-coated tablets for recurrent respiratory infection （RRI） of children. Methods 98 children aged 3 - 5 years old with a confirmed diagnosis of RRI in our hospital from September 2003 to September 2006 were selected randomly and divided into two groups ： study group （ n = 50） and control group （ n = 48） with permissions of children＇ sparents. The children in the study group were given extra oral administration of thymopeptidum enteric-coated tablets with a dose of 5mg/ day for 3 months as a course of treatment, while those children in the control group only received routine treatment, All the children were registered and they visited the pediatrician every month and were given an evaluation every half a year and continuous observation for over one year, Results The total effective rate in the study group （92. 0% ） was significantly higher than that in the control group （66.7%） （P 〈 0. 01 ）, there was a significant difference between the two groups. What＇s more, number of children whose disease was controlled and the disease controlled rate in the study group （25 children, 50% ） were significantly higher than those in the control group （ 10 children, 20, 8% ） , and there were significant differences between the two groups （ both P 〈 0.01 ）. Conclusion Thymopeptidum enteric-coated tablets has a distinctive effect of preventing children from recurrent respiratory infection, and till now no adverse responses of children have been reported. It is easily absorbed and well accepted by children and is worthy to be popularized in clinic.