急性脑缺血并发肺损伤的实验研究

Acute cerebral ischemia with lung injury:An experimental study

目的：探讨脑缺血早期肺部损伤的发生机制及其在临床救治中的重要性。方法：结扎１２只大鼠双侧颈总动脉２小时，造成脑缺血模型。观察脑缺血动物呼吸和心率的变化及２小时后动脉血ｐＨ、氧分压（ＰａＯ２）和二氧化碳分压（ＰａＣＯ２）；并处死动物取脑和肺组织作病理学观察。结果：脑缺血大鼠ＰａＣＯ２显著升高，ＰａＯ２显著降低；肺部可见肺泡隔增宽、充血、肺泡Ⅰ型上皮细胞肿胀、线粒体嵴结构不清、肺泡Ⅱ型上皮细胞板层体内环形排列的板层结构破坏。结论：实验组动物，脑缺血早期肺部已有损伤。因此，对于急性缺血性脑血管病患者应早期纠正脑缺氧，改善肺功能，防止或降低肺部感染的发生。

Objective:To investigate the pulmonary injury in early cerebral ischemia.Methods:Bilateral common carotid arteries of 12 rats were ligated for 2 hr to create acute cerebral ischemia.Results:pH and PaCO 2 were markedly increased and PaO 2 was markedly decreased 2hr after cerebral ischemia occurred in rats.Alveolar septa were congested and widened.Type I alveolar epithelia were swollen,the structure of mitochondrial creasts was not clear,and the circular structure of multilamellar body in type Ⅱ alvecolar epithelia was destroyed.Conclusions:Experimental result suggests that the lung was injured in the early stage of cerebral ischemia.