摘要
目的:探讨经皮冠状动脉腔内成形术(PTCA)是否影响冠状动脉硬化性心脏病患者的内皮细胞功能。方法:用放射免疫法测定17例冠状动脉硬化性心脏病患者PTCA前后血浆内皮素1(ET1)和6酮前列腺素F1α(6ketoPGF1α)的含量。结果:PTCA后血浆ET1和6ketoPGF1α水平均升高,术后24小时达高峰,ET1增至术前的2.56±0.94倍(P<0.01),6ketoPGF1α增至术前的1.42±0.74倍(P<0.01),7天后降至接近术前水平。结论:PTCA可刺激内皮细胞释放血管活性物质。
Objective:To investigate whether percutaneous transluminal coronary angioplasty (PTCA) influences the function of endothelial cells.Methods:Plasma le vels of endothelin1 (ET1) and 6ketoPGF 1α in 17 patients with coronary artery disease were determined by radioimmunoassay before and after PTCA.Results:A remarkable increase of plasma ET1 and 6keto PGF 1α was found after PTCA.They reached to peak levels 24hr after PTCA.ET1 increased to 2 56±0 94 of its initial value ( P <0.01)before the procedure and 6ketoPGF 1α to 1 42±0 74.These increased values returned to the normal range by 7 days.Conclusions:PTCA can stimulate the endothelial cells to release vasoactive substance.Hence,it is necessary to prevent coronary artery spasm after PTCA.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第2期83-84,共2页
Chinese Critical Care Medicine
基金
湖北省九五科技攻关项目
关键词
冠心病
内皮素
前列环素
PTCA
ET-1
percutaneous transluminal coronary angioplasty
endothelin
prostacyclin