血浆血栓素A_2和前列环素在不稳定型心绞痛发病中的意义

Effects of plasma thromboxane A 2 and prostacyclin on attack in patients with angina pectoris/

目的：探讨血管活性物质血栓素Ａ２（ＴＸＡ２）和前列环素（ＰＧＩ２）在不稳定型心绞痛发病中的作用。方法：测定５３例冠状动脉粥样硬化性心脏病（冠心病）患者血浆血栓素Ｂ２（ＴＸＢ２）和６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α）含量的变化。结果：不稳定型心绞痛３２例与稳定型心绞痛２１例比较，不稳定型心绞痛组血浆ＴＸＢ２的含量显著升高，为稳定型心绞痛组的３．９１倍（Ｐ＜０．００１）；ＴＸＢ２／６ｋｅｔｏＰＧＦ１α比值也明显高于稳定型心绞痛组（Ｐ＜０．００１）。结论：冠心病心绞痛发作时存在的血浆ＴＸＢ２含量异常增高，ＴＸＢ２与６ｋｅｔｏＰＧＦ１α平衡失调，导致冠状动脉舒缩障碍、痉挛等改变而致心绞痛发生。

Objective:To investigate effects of vasoactive substances,such as plasma thromboxane A 2 (TXA 2) and prostacyclin (PGI 2),on attack in patients with unstable angina pectoris.Methods:There were 53 patients with coronary atherosclerotic heart disease whose plasma concentrations of thromboxane B 2 (TXB 2) and 6ketoprostaglandin F 1α (6ketoPGF 1α ) were measured by radioimmunoassay.Results:The data showed that the level of plasma TXB 2 was significantly higher in 32 patients with unstable angina pectoris(3 19fold) than in 21 patients with stable angina pectoris( P <0 001).Meanwhile,the ratio of TXB 2 to 6ketoPGF 1α was markedly higher in unstable angina pectoris group than in stable angina pectoris group( P <0 001).Conclusions:The results suggest that the increase of plasma TXB 2 concentration and the imbalance of prostacyclinthromboxane B 2 may induce the dysfunction of vasodilatation and vasoconstriction of the coronary artery,subsequently leading to the occurrence of angina pectoris.