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基于杂交的基因差异表达技术在人胃癌研究中的应用

Application of hybridization based differential gene expression in the screening of genes associated with human gastric carcinoma
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摘要 寻找胃癌与正常胃黏膜及癌旁组织的差异基因对全面阐明胃癌发生发展及转移的分子机制具有重要意义。目前,基于杂交的基因差异表达分析技术已广泛用于寻找疾病以及细胞生长发育不同阶段的相关基因。此文就基于杂交的基因差异表达技术的原理、特点以及在人胃癌研究中的应用作一综述。 To investigate the differential gene expression profiles is very important to understand the molecular mechanism of carcinogenesis, progression, metastasis and the diversity of gastric carcinoma. This update reviews the application Of hybridization based differential gene expression in the screening of genes associatied with human gastric carcinoma.
作者 陈怡 姒健敏
出处 《国际消化病杂志》 CAS 2007年第4期278-280,286,共4页 International Journal of Digestive Diseases
关键词 基因差异表达 抑制消减杂交 CDNA微阵列 胃癌 Differential gene expression Suppression subtractive hybridization DNA Microassay Human gastric carcinoma
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  • 1Du-Hu Liu Xue-Yong Zhang Dai-Ming Fan Yu-Xin Huang Jin-Shan Zhang Wei-Quan Huang Yuan-Qiang Zhang Qing-Sheng Huang Wen-Yu Ma Yu-Bo Chai Ming Jin Institute of Digestive Disease,Xijing Hospital,~2 Department of Gastroenterology,Tangdu Hospital,~3Department of Histology and Embryology,~4 Department of Microbiology,~5 Department of Biochemistry,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China.Expression of vascular endothelial growth factor and its role in oncogenesis of human gastric carcinoma[J].World Journal of Gastroenterology,2001,7(4):500-505. 被引量:37
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