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乙型肝炎病毒X蛋白与肝癌研究进展 被引量：3

Recent advances in relationship between hepatitis B virus X protein and hepatocellular carcinoma
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摘要 X蛋白(HBx)被认为是乙型肝炎病毒(HBV)致原发性肝癌(HCC)的重要物质,具体机制不明,己成为研究的热点之一。近年来对HBx致肝癌机制的研究显示,HBx是一种多功能的病毒蛋白,有转录调控作用,对肝细胞内许多癌基因和/或抑癌基因的表达有直接或间接影响,可影响细胞的生存、增殖和凋亡,调节转录因子活性,促进细胞的侵袭和转移等,在肝癌形成中起重要作用。 Hepatitis B virus X protein （HBx） is believed to be involved in hepatocarcinogenesis, although its oncogenic role remains controversial. HBx is a multifunctional regulator that modulates transcription, directly or indirectly interacting with the expression of oncogenes and anti - oncogenes, affects cell survival, proliferation and apoptosis, and increases invasive potential and migration, which may contribute importantly to hepatocarcinogenesis.
作者 崔彦芝 罗荣城
机构地区 南方医科大学南方医院肿瘤中心
出处 《癌症进展》 2007年第4期324-328,332,共6页 Oncology Progress
关键词 X蛋白 原发性肝癌 乙型肝炎病毒 机制 X protein hepatoeellular carcinoma hepatitis B vires mechanism
分类号 R735.7 [医药卫生—肿瘤]
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共引文献59

同被引文献66

  • 1王小众,林纳.HBV X基因和X蛋白的功能[J].世界华人消化杂志,2006,14(26):2579-2585. 被引量：9
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癌症进展
2007年 第4期

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