神经症患者超氧化物歧化酶、谷胱甘肽超氧化物酶及脂质超氧化物含量的变化

A study on levels of superoxide dismutase, glutathione peroxidase and lipid peroxide in patients with neurotic disorder

为研究氧自由基与神经症之间的关系，分别采用邻苯三酚自氧化法、二硫对硝基苯甲酸直接法、硫代巴比妥酸比色法，测定了８７例神经症和５５名健康人超氧化物歧化酶（ＳＯＤ）、谷胱甘肽超氧化物酶（ＧＳＨ－Ｐｘ）和脂质超氧化物（ＬＰＯ）含量。结果显示，神经症组ＳＯＤ与ＧＳＨ－Ｐｘ两种酶含量均低于对照组，神经症组治疗前低于治疗后；ＬＰＯ为治疗前高于治疗后，差异均有显著性。从单胺类的代谢与生成氧自由基的生化联系以及机体内ＳＯＤ、ＧＳＨ－Ｐｘ、ＬＰＯ之间的相互关系上对结果进行了分析，提示体内单胺类物质代谢过程中产生的氧自由基在神经症的病理过程中可能发挥一定的作用。

To evaluate the role of oxygen free radicals in pathology of neurosis, the levels of superoxide dismutase (SOD), gluathione peroxidase (GSH Px) and lipid peroxide (LPO) in 87 neurotic patients and 55 normal subjects were measured using pyrogallic acid auto oxidation method, dithio bis (2 nitrobenzonic acid)(DTNB)method and thiobarbituric acid colorimetric method. The results showed levels of SOD and GSH Px were significantly lower in the patients with neurotic disorder than that in normal controls. After treatment, the SOD and GSH Px levels were significantly elevated but LPO level was significantly decreased in the patients. The results suggested oxygen free radicals produced in the process of monamine metabolism might play a role in the pathology of neurotic disorder.