插指状细胞在重症肌无力患者非瘤性胸腺内的变化

Interdigitating cells in nonneoplastic thymus of patients with myasthenia gravis

探讨胸腺内插指状细胞（ＩＤＣ）在重症肌无力（ＭＧ）发病中的作用。方法采用Ｓ－１００蛋白抗体用免疫组织化学方法对３０例ＭＧ患者非瘤性胸腺内Ｓ－１００蛋白阳性ＩＤＣ的分布和数量观察研究。同时取１０例不同年龄的正常胸腺作对照。结果ＭＧ非瘤性胸腺内ＩＤＣ数目明显增多（Ｐ＜０．０５），且ＩＤＣ数目的多少和胸腺髓质上皮细胞的增生程度呈正相关。结论ＩＤＣ可能参与ＭＧ的发病，胸腺髓质内增生的上皮细胞在ＭＧ自身免疫过程中起一定作用。

Objective The authors made a study of the role of interdigitating cells (IDC) in the pathogenesis of myasthenia gravis (MG) study. Method The distribution and number of S 100 protein positive interdigitating cells in nonneoplastic thymus were examined in 30 patients with mysthenia gravis, using the ABC immunohistochemical methods. The specimens of thymus taken from 10 cases of non myasthenic patients of various ages were taken as controls.Results Showed that IDC were distributed in the medullary as well as in the corticomedullay junction areas in the nonneoplastic thymus of the myasthenic patients. The number of IDC in the medulla of myasthenic thymus was increased significantly as compared with that in the non myasthenic patients. The increase was more prominent in those areas the hyperplasia of the medullary epithelial cells were found. Conclusion The authors considered that IDC might participate in the pathogenesis of MG and the medullary epithelial cells might trigger off the cascade of the autoimmune process in myasthenia.