摘要
Objective： To investigate the therapeutic effects and adverse reaction of acupuncture plus medication and single medication for post-stroke depression（PSD）. Methods： In an open control study, 93 cases of the patients with depression were randomly allocated to three groups： 30 cases in the acupuncture-medication group （AM）, 30 cases in Prozac Group A （A）, and 33 cases in Prozac Group B （B）. The acupuncture-medication group was treated by oral administration of Prozac 20 mg/d plus acupuncture. Prozac Group A was treated by oral administration of Prozac 20 mg/d. Prozac Group B was treated by oral administration of Prozac 20-40 mg/d. All three groups were treated for 6 weeks. The therapeutic effects and adverse reaction were evaluated by Hamilton Depression Scale （HAMD） and Treatment Emergent Symptom Scale （TESS） respectively in the three groups. Results： The effective rate was 86.7% in the acupuncture-medication group, 63.3% in Prozac Group A and 87.9% in Prozac Group B. The therapeutic effect was better in the acupuncture-medication group than in Prozac Group A, and there was no significant difference in comparisonwith Prozac Group B （P〉0.05）. But the occurrence rate of drug adverse reaction was higher in Prozac Group B than in the acupuncture-medication group. Conclusion： Simultaneous application of acupuncture and medication is a therapeutic method with affirmative effect and less side effect for post-stroke depression.
目的：照观察针药结合与单纯西药治疗中风后抑郁症（PSD）的疗效及不良反应。方法：采用开放性对照研究方法，将93例抑郁症患者随机分为三组，针药组30例、百忧解A组30例、百忧解B组33例。针药组口服百忧解20mg／d并加以针刺，百忧解A组口服百忧解20mg／d，百忧解B组口服百忧解20～40mg／d；三组治疗时间均为42d，以汉密尔顿抑郁量表（HAMD）及副反应观察量表（TESS）分别观察三组的疗效及不良反应。结果：针药组有效率为86．7％，百忧解A组为63．3％，百忧解B组为87．9％，针药组疗效优于百忧解A组，与百忧解B组疗效差异无统计学意义（P〉0．05），但药物不良反应发生率百忧解B组高于针药组。结论：药并用是脑卒中后抑郁症的一种疗效确切且副反应少的治疗方法。
