E-钙粘蛋白与肺癌侵袭转移

E-cadherin in lung cancer invasion and metastasis

E-钙粘蛋白(E-cadherin,E-cad)是一类介导细胞与细胞间相互黏附、具有维持组织结构完整性和极性的钙依赖性跨膜糖蛋白。较多研究证实E-cad与多种上皮恶性肿瘤的分化、侵袭、转移和预后相关。本文就E-cad的结构功能、在肿瘤侵袭转移中的作用机制、与肺癌的关系及血清可溶性E-cad检测的临床意义作一综述。

E-cadherin（ E-cad）is a member of the cadhcrin superfamily known as a calcium-dependent membrane glycoprotein, mediating the cell to cell adhesion interactions and maintaining integrity and polarity of tissue architecture. Recent studies have shown that E-cad plays an important role in many epithelial malignant tumors differentiation, invasion, metasitasis and prognosis. This review summarizes E-cad＇s structure and function, mechanism in tumor invasion and metastasis, relationship with lung cancer and the clinical significance of serum-soluble E-cad.