富血小板血浆(PRP)治疗慢性难愈合伤口的初步经验

Apreliminary experience of platelet-rich plasma (PRP) For healing cutaneous chronic wounds

目的观察自体富血小板血浆对慢性难愈合伤口创面的修复作用。方法12个创面中，糖尿病性溃疡4例，创伤性溃疡3例，压迫性溃疡3例，神经性溃疡2例。创面清创后用PRP凝胶修复，然后定期比较PRP与全血中的血小板计数，观察创面愈合情况。结果PRP的血小板计数约为全血的5～8倍。用PRP修复的12例中，创面完全愈合7例，部分愈合3例，皮瓣转移后愈合2例。结论PRP凝胶对慢性难愈合伤口有明显的修复作用，且应用安全，无痛苦。

Objective To observe the effects ofplatelet-rich plasma（PRP） on the healing of cutaneous chronic wounds. Methods Twelve wounds from diabetes, trauma, pressure sore, neuropathy were treated with platelet-rich plasma. Before PRP gel was applied, a surgical debridement was carried out. The count ofplatelet in PRP and whole blood, the healing of wounds was used to evaluate the treatment results. Results the count ofplatelet in PRP is 5 - 8 times than that of whole blood. In all of cutaneous chronic wounds, complete response was observed in 7 patients, 3 had partial response, 2 were subjected to cutaneous graft. Conclusion The results indicate that application of PRP gel can accelerate the healing of chronic wounds in clini, No adverse reaction was found, and pain was reduced in every treated patient.