女性生殖道人乳头状瘤病毒感染的治疗

Treatment of female patients with vaginal and cervical HPV infection

目的研究中药治糜灵栓与干扰素α-2a治疗女性生殖道人乳头状瘤病毒(HPV)感染的疗效对比。方法共收集临床186例HPVDNA检测阳性,宫颈组织学检查证实宫颈炎、宫颈上皮内瘤样病变(CIN)Ⅰ级患者,随机分两组,A组94例采用纯中药制剂治糜灵栓自行放置于阴道后穹隆,隔晚1次,每次1枚,每月10次为一疗程,B组92例采用干扰素阴道栓剂淑润栓同法治疗对照以观疗效。结果资料显示两组患者HPVDNA转阴率相似,分别为93.6%和93.5%,差异无统计学意义(P>0.05)。结论中药治糜灵栓价格明显低于淑润栓,更宜推广应用于女性生殖道HPV感染的患者使用。

Objective To evaluate the efficacy of Chinese traditional medicine ZMLS versus IFN-α-2a in treating HPV infection. Methods A total 186 patients with HPV infection evidenced by positive HPV DNA were randomized into 2 groups： Treatment group （n=94）, treated with Chinese traditional medicine ZMLS intravaginal suppository, one pill qod for 10 days. Control group （n = 92）, treated with IFN-α-2a intravaginal suppository, one pill qod for 10 days. Adverse effects were observed. Results The efficacy rate was 93.6% in the treatment group and 93.5% in control group （P〉0.05）. Conclusions Chinese traditional medicine ZMLS is much less expensive than IFN-α2a. It can be used for the treatment of female patients with vaginal and cervical HHPV infection.