单纯性重症颅脑损伤应用生长激素的血糖观察

Serum Glucose in Severe Craniocerebral Trauma Under Sometropin Therapy

目的对单纯性重症颅脑损伤病人应用重组生长激素,以观察生长激素对此类病人血糖的影响。方法前瞻性、随机将66例单纯性重症颅脑损伤病人分为对照组和实验组,两组病人都接受常规的治疗。实验组于受伤后第3天开始用重组生长激素,疗程10 d。分别测定两组在受伤后3～13 d 的血糖、糖耐量、血胰岛素(Is)的变化。结果两组的糖耐量值,在受伤后早期都出现异常,2周后实验组与对照组的糖耐量都恢复正常,两组对比无显著性差异。结论在单纯性重症颅脑损伤病人中每日使用8 u 重组生长激素不会加重颅脑损伤病人已有的糖耐量异常。

Objective To study the effect of somatropin（ rhGH, recombinant human growth hormone） on serum glucose in patients with simple and severe craniocerebral trauma, Methods 66 patients were randomly and equally divided into two groups, control group and therapeutic group. The patients of therapeutic group received 8 u rhGH/day for 10 days. Serum glucose level,glucose tolerance test and serum insulin level（IS） were assayed on 3^rd ,8^th and 14^th day. Results The serum glucose levels,glucose tolerance test and serum insulin levels of patients of both groups showed abnormal values on the 3^rd and 8^th day after head injury and there was no significant difference between them. But the values of these three tests resumed to the normal range on the 14^th day. Conclusion Somatropin did not induce and additionally adverse effect on patients＇ abnormal metabolism of glucose caused by head injury.