原发性皮肤小B细胞淋巴瘤

A case of primary cutaneous B small cell lymphomas

报告1例原发性皮肤小B细胞淋巴瘤。患者男,62岁。反复低热4年,躯干暗红斑、斑丘疹1年。外周血白细胞和淋巴细胞计数正常,IgM56 100mg/L,κ轻链(freeк)21.73g/L,尿本-周蛋白阳性。3次骨髓穿刺均显示增生性骨髓像。皮损组织病理检查:真皮层及胶原束间密集淋巴样细胞浸润,免疫组化染色结果示肿瘤细胞CD20、CD79a、CD5、CD10、部分CD23、bcl-2均(+),UCHL1、CD4、CD8、CD38、cyclinD1均(-)。组织病理改变符合小B细胞淋巴瘤。诊断:原发性皮肤小B细胞淋巴瘤。

A case of primary cutaneous B small cell lymphomas was reported. A sixty-two years old man presented with febrile relapse for 4 years, and dark erythema and maculopapulae on the trunk for 1 year. Blood routine lest showed normal leucocyte and lymphocyte counts, and immuno-globnlin detection showed IgM 56.10 g/L,Kappa light chain 21.73 g/L. Urine Bence Jones protein was positive （free κ）. Bone marrow biopsy showed proliferation images. Skin biopsy revealed a sheet of intensive lymphoid cell infiltration on dermal and collagen, hnmunohistochemical stains indicated tumor cell were： UCHL1（-）, CD4（-）,CD8（-）.CD20（＋）, CD79a（＋）, CD38（-）, CD5（＋）, CD10（＋）, part of CD23（＋）, bcl-2（＋）, cyclin D1（-）, which coincided with B small cell lymphomas. Based on the above findings, diagnosis of primary cutaneous B small cell lymphomas was made.