127例胃病幽门螺杆菌L型感染与胃癌的研究

Study on Detection of Helicobacter Pylori L-form in 127 Cases Gastric Disorders and Gastric Cancer

目的：探讨幽门螺杆菌L型（HP－L型）感染与胃癌、癌前病变及慢性胃炎的关系。方法：用组织切片革兰染色和免疫组化法，对36例胃腺癌、34例细胞不典型增生、42例慢性胃炎及15例正常组织进行HP－L型检测。结果：胃癌、不典型增生及慢性胃炎的Hp－L到检出率分别为80．6％、79．4％和73．8％，明显高于正常组织（467％），并有统计学意义（P＜0．05）。而前三种类型组织中的Hp-L型检出率无显著性差异（P＞0．05）。结论:Hp-L型感染与胃癌、癌前病变及慢性胃炎有关，且Hp-L型感染在胃癌的发生中可能起一定作用。

Purpose: To investigate the relationship between helicobacter pylori L-form infection and gastric cancer, precancerous lesions, chronic gastritis. Methed: 36 cases gastric cancer(GA), 34 cases atypical hyperplasia(AH), 42 cases chronic gastritis(CG) and 15 cases normal tissue associated with helicobacter pylori L-form(Hp-L) were examined by Gram's staining and lmmunohistochemical. Rusults: The result showed that the positive rate of the infection Hp- L in GA, AH and CG were 80. 6 % (29/36), 79. 4 % (27/34 ) and 73. 8 % (31/42) respectively, the infection Hp-Lin lesions tissue were significantly higher than those in normal tissue(P＜0. 05 ). The positive rate of infection Hp-L in three lesions tissue were not significantly different respectivcly(P＞0. 05). COnclusion:It suggests that the infection of Hp-L in gastric tissues is correlated with GA, AH and CG, and may be one of the causes of gastrocarcinogenesis mechanisms.