高分子材料作为抗癌药载体动脉灌注的动物实验研究

FOUNDATIONAL STUDY OF INTRAARTERIAL INFUSION WITH HIGH-MOLECULEMATERIALS AS CARRIERS OF ANTICANCER AGENT

研制一种既能使抗癌药缓释，又安全可靠的药物载体。方法观察高分子材料体外理化特性，并通过犬血管灌注和含阿霉素（ＡＤＭ）犬肝动脉灌注，测定灌注后ＡＤＭ浓度，并取主要脏器行组织学检查。结果单纯肝动脉ＡＤＭ注射组的药物峰值较高（１３．３ｕｇ／ｍｌ）下降迅速。Ｓ１－ＡＤＭ加Ｓ２－ＡＤＭ灌注组的峰值较低（４．３ｕｇ／ｍｌ和３．２ｕｇ／ｍｌ）下降缓慢，与单注组有显著性差异〔Ｐ＜０．０５），Ｓ１，Ｓ２两组间差异无显著性（Ｐ＞０．０５）。

jective To study and manufacture a transporter of anticancer agent. The transporter could release anticancer drug slowly as carrier of anticancer drug.Method The author study physical and chemical character in vitro arterial infusion of high - molecuJe materials(HMM) and release of ADM from the S1 ,S2-ADM complexes.Result HMM could release anticancer drug slowly as carrier of anticancer drug. The peak level of single - ADM infusion was high ( 13. 3 ug/ml) and dropped rapidly. The peak levels of S1 - ADM and S2- ADM were relatively 1ow and dropped slowly. The difference was statistically significant(P< 0. O5) compared with single - ADM. Conoclu - sion HMM has potential as a transtporter of anticancer agent for prolonged release and more homageneous distribution in intraarterial infusion,