肾衰康组成中药对低分子尿毒症毒素的体外吸附作用

In Vitro Adsorption of Chinese Herbs with Shen Shuai Kang on Low-molecular Uremic Toxins

目的:观察肾衰康中各单味中药对尿素氮、肌酐、尿酸的体外吸附作用,探索肾衰康冲剂对尿毒素清除的作用机理。方法:用不同中药制成的水煎剂和焙干研末配制成50、100、150mg/ml浓度分别与尿素、肌酐、尿酸混合液作用,分别作用30、60、90、120min后离心,测定各组液体中残余尿毒素浓度。结果:煅牡蛎、枳壳煎剂50mg/ml组尿素、肌酐的浓度较对照组明显下降(P<0.05),100、150mg/ml组中各尿毒素都有明显下降(P<0.01)。焙剂则各组下降均有非常显著差异(P<0.01)。100mg/ml的煎剂及焙剂30min后下降差异即明显持续至90min后趋于恒定,在30、60、90min组中随时间延长,药物对尿毒素的吸附量增加。结论:肾衰康中5味中药对体外配制的尿素氮、肌酐、尿酸有下降作用,可能的机制是直接吸附作用。

Objective： To observe the adsorbent effect of durgs on uremic toxic, and to explore the mechanism of Chinese durgs adsorbent uremic toxic. Methods： 1 different dose of Chinese durgs were added to uremic toxic solution then the concentrations of uremic toxins were measured on 60 min 2 The same dose of Chinese drugs were added to uremic toxic solution then the concentrations of uremic toxins were measured at different time spots. Results： 1 The concentrations of toxins decreased is significantly on midst and large dose group 2 The time longer the concentrations of toxins lower among the 30, 60,90 min group. Conclusion： Sheng Shuai Kang＇s composition chinese durgs can well lower these uremic toxin in vitro,the possible mechanism is direct adsorption.