天香丹对冠心病病人血管内皮生长因子及相关因子的影响

Effect of Tianxiangdan on Serum Vascular Endothelial Growth Factor and Correlative Factors in Coronary Heart Disease

目的探讨天香丹对稳定型心绞痛病人血清血管内皮生长因子(VEGF)、一氧化氮(NO)以及一氧化氮合酶(NOS)含量的影响。方法99例冠心病稳定型心绞痛病人随机分为3组,治疗组36例,在西医基础治疗上加天香丹18g/d;对照Ⅰ组34例,在西医基础治疗上加通心络胶囊每日12粒,对照Ⅱ组29例,西医基础治疗基础上加硝酸酯类,28d为1个疗程,观察病人治疗前后心绞痛发作频率和持续时间、心电图的变化,并观察血清VEGF,NO以及NOS含量的变化。结果治疗组与对照Ⅱ组心绞痛发作次数比较,差异有统计学意义(P<0.05)。治疗组、对照Ⅰ组和对照Ⅱ组的心电图总有效率分别为83.33%,70.59%和68.97%,差异无统计学意义(P>0.05)。治疗组治疗后血清NO和VEGF含量与对照Ⅱ组比较,差异均有统计学意义(P<0.01)。结论天香丹可提高血清VEGF,NO以及NO的含量,促进冠状动脉侧支循环的建立,改善心肌缺氧状态,从而达到治疗冠心病的目的。

Objective To investigate the effect of Tianxiangdan on serum vascular endothelial growth factor （VEGF）, nitric oxide （NO） and oxide nitric synthase （NOS） in patients （pts） with stable angina pectoris. Methods Ninety-nine pts with stable angina were randomized into three groups： Treatment group （n = 36） treated with a basic western medicine and Tianxiangdan; control group Ⅰ （n = 34） treated with basic western medicine and Tongxinluo Capsule, and control group Ⅱ （n = 29） treated with basic western medicine and isosorbide dinitrate tablet. The levels of serum VEGF, NO and NOS were measured before and after therapy in all pts. Results The effective rate in ECG was 70,59% in control group Ⅰ , 68.97% in control group Ⅱ and 83.33% in treatment group, The frequency of angina and duration of the angina were different significantly in the three groups （P 〈 0.01 ）. The levels of VEGF and NO were obviously elevated in three groups （P 〈 0.01 ）. Conclusion Tianxiangdan could elevate the levels of serum VEGF, NO and NOS and improve the oxygen supply in coronary heart disease.