苦参素可促进大鼠小肠手术后消化道动力

Oxymatrine promotes the alimentary motility after enterorrhaphy in rats

目的:观察苦参素对大鼠小肠手术后消化道动力的作用。方法:大鼠禁食不禁水16小时,2ml/只钡剂灌胃后,水合氯醛麻醉,腹部正中切口开腹,在盲肠上10mm处的小肠切开约1/2～1/3的环形切口,间断缝合后关闭腹腔。术后单笼饲养,肌肉注射苦参素,每天1次连续3天,观察大鼠首次排出白色粪便的时间、钡剂排尽的时间和36小时大便湿重。结果:苦参素50mg/kg、100mg/kg剂量可使小肠手术后大鼠的首次排出的钡剂时间和钡剂排尽的时间比模型对照组明显提前,36小时大便湿重明显增加。结论:苦参素能明显促进大鼠小肠手术后的消化道动力。

Objective： To investigate the effect of oxymatrine on alimentary motility after enterorrhaphy in SD rats. Methods： After fasted for about 16h, the animals were administered baralyme per os. Then anesthetized with chloralhydrate, the rat＇s abdomen was exposed via a midline incision. The enterotomy was carried out at the intestine 10mm above the cecum, and the incision was closed with sutures. After administered the oxymatrine intramuscularly the animals were returned to their cages for recovery. The drug was given once a day and continued for 3 days after the operation. The first discharge time and the completed time of white defecation as well as the 3 days whole stool wet weight were observed. Results： With the doses of 50 mg/kg and 100 mg/kg, the first discharge time of white defecation and the completed time of white defecation were much earlier in drug treated groups than in model control group, and the 3 days whole stool wet weight was much increased compared to the model control. Conclusion： These results indicated that the oxymatrine could promote the alimentary motility after the enterorrhaphy of SD rats.