脑心通对不稳定型心绞痛患者血管内皮功能及超敏C反应蛋白的影响

Effect of Naoxintong Capsules(脑心通胶囊) on endothelial function and high-sensitive C-reaction protein of patient with unstable angina pectoris

目的:探讨脑心通胶囊对不稳定型心绞痛(UPA)患者血管内皮功能及超敏C反应蛋白(hs-CRP)的影响。方法:76例UPA患者随机分为常规治疗组和常规治疗+脑心通组,观察治疗3月前后血清ET、NO、hs-CRP,并利用超声测定肱动脉血流介导的血管扩张变化率(FMD)。结果:治疗后两组患者血清hs-CRP、ET水平均明显下降(P<0.01),NO水平和FMD均升高(P<0.05或P<0.01);治疗后脑心通组血清ET、hs-CRP水平均低于常规治疗组(P<0.01),NO水平和FMD高于常规治疗组(P<0.01)。结论:脑心通可能通过降低血清ET水平,升高NO水平改善血管内皮功能及减轻冠状动脉粥样斑块的炎症反应等途径取得临床疗效。

Objective： To observe the effects of Naoxintong capsules on endothelial function and high - sensitive C - reaction protein （ hs - CRP） of patients with unstable angina pectoris （UPA）. Methods： 76 patients with UPA were divided randomly into Naoxintong group and control group ,measure the content of endothelium and hs -CRP and Flow- mediated dilatation（FMD） before and after treatment for 3 month. Resuits： Naoxintong Capsules can decrease ET and hs - CRP, and increase the content of NO in serum,also ameliorate FMD. Conclusion： Naoxintong Capsules can partially stave off atherosclerotic inflammation and meliorate endothelial function.