摘要
目的观察凝血因子VII(coagulationf actor VII,FVII)R353Q基因多态性在华南汉族健康者人群中的分布。方法提取华南汉族60名正常健康者基因组DNA,应用多聚酶链反应(PCR)技术和限制性内切酶片段长度多态性技术检测上述人群的FVII R353Q基因型。结果华南汉族人群FVII基因R353Q具3种基因型(RR,RQ,QQ),FVII等位基因R、Q基因频率在人群中分别为90.9%,9.1%。基因型频率符合Hardy-Weinberg平衡定律。结论华南汉族健康人群凝血因子VII基因R353Q多态具3种基因型(RR,RQ,QQ),R等位基因携带频率明显高于Q等位基因。
Objective To study the distribution of coagulation factor VII gene R353Q polymorphisms in Chinese Han population in the south of China, Methods Genotypes R353Q polymorphisms of FVII were typed in 60 healthy subjects in the south of China by polymerase chain reaction - restriction fragment length polymorphism. Results Three gene types (RR, RQ, and QQ) of R353Q polymorphisms were seen, FVII allelic frequencies of R and Q were 90.9% and 9.1% in the 60 healthy subjects respectively. Genotype distribution was in accordance with Hardy - Weinberg equilibrium. Conclusion There are three types R353Q polymorphisms of the FVII gene in Han Chinese in the southern of China.
出处
《实用预防医学》
CAS
2007年第4期1007-1008,共2页
Practical Preventive Medicine
基金
深圳市科技局立项(200405020)
暨南大学医学院立项(WSTJJ20030108440301510812251)
关键词
凝血因子VII
基因多态性
华南汉族
健康人群
Coagulation factor VII
Gene polymorphism
Han Chinese of southern China
Healthy population