复发性口腔溃疡中西医结合治疗的探讨

Integrated Traditional Chinese and Western Medicine in Treatment of Recurrent Oral Ulcer

目的观察中西医结合治疗复发性口腔溃疡的疗效和不良反应,并探讨其对患者免疫状况和血液流变学的影响。方法将我科80例复发性口腔溃疡患者随机分为西医常规治疗组(常规治疗组)和中西医结合治疗组(结合组),常规治疗组口服左旋咪唑和西米替丁,结合组在此基础上加服中药,观察二组患者的疗效和不良反应,并检测二组治疗前后外周血T淋巴细胞亚群值和血液流变学各项指标。结果结合组比常规治疗组疗效好,其差异有显著性(P<0.05);结合组外周血CD3、CD4及CD4/CD8比率提高程度显著优于常规治疗组,其差异有显著性(P<0.05);结合组血液流变学各项指标降低程度均显著优于常规治疗组,其差异有显著性(P<0.05);二组患者均无不良反应。结论中西医结合治疗复发性口腔溃疡,疗效可靠,能明显减少患者复发次数和程度,溃疡面愈合时间短,无明显不良反应,并能提高患者机体的免疫功能、改善血液流变等,可广泛应用于临床。

Objective To observe efficacy and adverse reaction of combining traditional Chinese and western medicine treatment of recurrent oral ulcer （ROU）; and to know the patient＇s immune status and the impact on blood rheology. Methods Eighty patients with ROU were randomly assigned into conventional treatment group and combination treatment group. The conventional treatment group received oral levamisole and cimetidine, the combined group received additional traditional Chinese herbal medicine,the efficacy and adverse reactions were compared. In addition, before and after treatment, peripheral T- lymphocyte subsets and indexes of blood rheology were monitored. Results Combination group presented better efficacy than that of the conventional group, a significant difference was observed（P〈 0.05）. CD3, CD4 count and CD4/CD8 ratio in the combination group were significantly increased than those of the conventional group, and the difference was significant（ P〈 0.05）. Decreased indicators of blood rheology in the combination group were significantly superior to the conventional treatment group, and the difference was significant （P〈 0.05）. No adverse reaction during treatment was found in these two groups. Conclusions Combining traditional Chinese and western medicine treatment of ROU can significant reduce ,the recurrence rate and ulcer extent and improve patient＇s immune function and blood rheology; it can be widely used in clinical practice.