多发性硬化症患者血清UA及CRP水平联合检测的临床意义

Clinical Significance of Combined Detection of Serum UA and CRP in Multiple Sclerosis

目的了解多发性硬化症(MS)患者血清UA和CRP浓度与病情的关系。方法采用定量尿酶法和免疫比浊法检测21例急性期和15例缓解期多发性硬化症(MS)患者和其它炎性神经系统疾病(OIND)患者血清UA和CRP浓度。结果MS急性原发组UA浓度明显低于OIND组(P<0.01),MS急性原发组UA浓度低于MS缓解稳定组(P<0.05)。MS急性原发组CRP浓度高于缓解恢复组和OIND组(P<0.05)。MS缓解恢复组和OIND组UA和CRP浓度无显著性差异。结论血清UA和CRP浓度与MS病情程度密切相关,UA和CRP的联合检测对MS的诊断、治疗及预后有重要临床意义。

Objective The relationship of serum levels of uric acid （UA） and C - reactive protein（CRP） in patients with multiple sclerosis （MS） was studied to find its clinical significance. Method Enzymatic and immunoturbidimetry methods were used to assess the serum level of UA and CRP in 21 patients with acute MS, 15 patients with relieved MS, and 30 patients with other inflammatory neurological disease （OIND） and the data were compared statistically. Results The serum level of UA in acute MS group was significantly lower than the relieved MS group（P〈0.05） and the OIND group（ P〈 0.01 ）. The serum level of CRP in acute MS Group was higher than the relieved MS group and the OIND group （P〈0.05）. Conclusions Variation of serum level of UA and CRP in patients with MS has clinical significance in diagnosis, therapy and prognosis.