新型袢利尿剂托拉塞米治疗心衰进展

Advances of a new loop diuretic torasemide on the treatment of heart failure

组织水肿是心衰发生、发展过程中的重要环节,袢利尿剂的应用是心衰治疗的重要组成部分。托拉塞米是一种新型的吡啶磺酰脲类袢利尿剂。近十余年的研究证实,托拉塞米在心衰的治疗方面有良好的作用:利尿作用更强、生物利用度更高、半衰期更长、作用更持久;对电解质、血糖、血脂代谢均无影响;主要在肝脏代谢。因此,对肾脏功能不全者不会产生蓄积,可以长期使用。本文就新型袢利尿剂托拉塞米治疗心衰的研究作一综述。

Tissue edema is an important stage of the occurrence and the development of heart failure. Loop diuretics play an important role in the treatment of heart failure. Torasemide is a new kind of loop diuretics, pertains to pyridine sulfonylurea loop diuretics. Recent decades of basic and clinical research had proved that, torasemide has an excellent effect in the treatment of heart failure, including better diuretic effect, higher biological availability, a relatively longer half - life, and does not affect the metabolism of electrolyte, blood glucose, blood fat. It is metabolized in the liver, therefore, patients with renal inadequacy can use it without accumulation. This article reviews on the research of torasemide in the treatment of heart failure.