四君子汤对环磷酰胺造模小鼠血清中SOD GSH CAT和MDA水平的影响

The Research of Variety of SOD GSH CAT and MDA in Cyclophosphamide Injuring Mice's Serum Resulted from the Effect of Sijunzi Decoction

目的:通过观察四君子汤对环磷酰胺造模小鼠血清中SOD、GSH、CAT和MDA水平的影响,探讨其对环磷酰胺所致小鼠毒副作用的保护机理。方法:以环磷酰胺损害ICR纯种小鼠,检测其血清中超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)和过氧化氢酶(CAT)的活力及丙二醛(MDA)的含量,观察四君子汤对环磷酰胺造模小鼠抗氧化能力的影响。结果:四君子汤组与环磷酰胺组相比均有显著性差异。结论:四君子汤能提高小鼠血清中SOD、CAT的活力和GSH的含量,降低小鼠血清中MDA的含量,这可能是四君子汤对环磷酰胺所致小鼠毒副作用的保护机理所在。

Objective： The purpose is to study the variety of SOD GSH CAT and MDA in Cyclophosphamide （CP） injuring mice＇s serum resulted from the effect of Sijunzi Decoction,and probe into the mechanism of protection of Sijunzi Decoction on CP injuring mice. Methods： The ICR mice injured by CP were treated with Sijunzi Decoction, and the variety of SOD GSH CAT and MDA in CP injuring mice＇s serum were mensurated. Results： Compared ,with the control group, SOD and CAT in Sijunzi Decoc- tion group were markedly activated,and the amount of GSH was observably enhanced. Conclusion： The improvement of antioxida- tion function may be one of the mechanism of protection of Sijunzi Decoction on CP injuring mice.