33例原发性肝癌病人血清游离脂肪酸谱的分析

The analysis of serum free fatty acid spectrum in 33 patienst with primary hepatocellular carcinoma

本文用气相色谱法（ＧＣ）测定３３例原发性肝癌（ＰＨＣ）病人血清游离脂肪酸（ＦＦＡ）谱，主要分析Ｃ１４∶０～Ｃ２２∶６ｎ－３ＦＦＡ的变化情况。结果表明：与正常人相比，ＰＨＣ病人血清的饱和脂肪酸及单不饱和脂肪酸有增高趋势，具有统计学意义（Ｐ＜０．００１）的有Ｃ１４∶０、Ｃ１６∶０、Ｃ１６∶１及Ｃ１８∶１；而多不饱和脂肪酸（ＰＵＦＡ）则趋于降低，有统计学意义（Ｐ＜０．００１）的有Ｃ１８∶２ｎ－６、Ｃ２０∶４ｎ－６、Ｃ２２∶６ｎ－３，还有Ｃ２０∶５ｎ－３（０．００１＜Ｐ＜０．００２），提示ＰＨＣ病人血清ＦＦＡ的组成及代谢发生变化。

The serum free fatty acid(FFA)spectrum were measured in 33 patients with primary hepatocellular carcinoma(PHC)by gas chromatography.The spectrum of FFA(from C14∶0 to C22∶6 n-3)in PHC patients were abnormal.Compared with control,the proportions of saturated and monounsaturated fatty acids in patients were significantly increased(P<0.001);and the proportions of polyunsaturated fatty acids (PUFA)significantly reduced(P<0.001).The results suggest that the composition and metabolism of the serum FFA were changed in patients with PHC and these may have some significance in explaining the abnormality of lipid metabolism in PHC and probing the mechanism of hepatocellular carcinoma