中国北方老年人骨代谢生化指标和髋部骨矿状态的季节变化(英文)

Seasonal changes in biochemical markers of bone metabolism and hip bone mineral status in older northern Chinese men and women

目的为了解北方老年人骨矿状态和骨代谢是否存在季节变化。方法沈阳市60-75岁老年人59人,其中男性30人,女性29人。于3月份（春季）和9月份（季秋）分别采集清晨空腹静脉血和尿,分析血浆中钙、磷、甲状旁腺激素、25（OH）D、1,25（OH）2D、骨钙素;尿中钙、磷、脱氧吡啶啉（DPD）。用DPX-L双能X线吸收仪（Lunar,USA）测定研究对象髋部骨密度和骨矿含量。结果男女血浆25（OH）D、钙（经血浆蛋白调整）和磷含量秋季均高于春季,而甲状旁腺激素含量秋季低于春季。男性血浆1,25（OH）2D含量秋季高于春季（P〈0.05）。女性尿中DPD/肌酐比值秋季低于春季（P〈0.05）。女性股骨径骨矿含量和全髋部骨密度秋季比春季分别高2.5%和1%（P〈0.05）。在男性全髋部骨密度秋季比春季高0.9%,但差异没有统计学意义。其它指标没有观察到季节变化。结论中国北方老年人维生素D营养状态、骨代谢和髋部骨矿状态存在季节变化。

Objective To evaluate whether bone metabolism and bone mineral status of this population differs by season. Methods： 30 men and 29 women aged 60 - 75 years from Shenyang, northern China were studied longitudinally in March （spring） and September （autumn）. Fasting plasma and urine were analysed for calcium, phosphate, PTH, 25（OH） D, 1 ,25（OH）2D, osteocalcin and free deoxypyridinoline （DPD）. Hip bone mineral status was measured using Lunar DXA （DPX-L, GE Lunar, Madison, US）. Results Compared with spring, 25 （OH） D, calcium （albumin adjusted） and phosphate were higher in autumn whilst PTH was lower in both men and women. In addition, 1,25 （OH）2D concentration was higher in men（ P 〈 0.05） but not in women and DPD/ Creatinine was lower in women but not in men, compared with spring. Femoral neck BMC and total hip BMD in autumn were 2.5% （SE1.1） and 1% （SE0.4） higher in women （P 〈 0.05）. An increase in total hip BMD [0.9% （SE0.5）] was also seen in men but not significant. No significant seasonal change was found with other markers in the studied and bone sites. Conclusion Seasonal changes in vitamin D status and Plasma PTH concentration are associated with seasonal changes in some markers of bone metabolism and bone mineral status at hip in an older northern Chinese population.