骨质疏松骨折血清骨钙素和尿脱氧吡啶酚变化的研究

A study on the variation of the level of serum osteocalcin and urine deoxypyridinoline in osteoporosis fracture patients

目的了解骨质疏松骨折患者在骨折愈合过程中骨代谢的变化,更好地指导临床有效的治疗。方法对80例骨折患者愈合过程中血清骨钙素和尿脱氧吡啶酚变化进行观察。结果骨质疏松性骨折后骨钙素呈增高趋势,可超出正常值范围。第3周达到最高峰,第6周逐渐下降到正常值范围;骨质疏松性骨折后尿脱氧吡啶酚亦呈增高趋势,完全超出正常值范围。第6周达到最高峰,第9周逐渐下降但未完全回复正常范围。结论骨质疏松骨折患者早期骨转换都很活跃,血清骨钙素和尿脱氧吡啶酚均增高,尿脱氧吡啶酚的增高较血清骨钙素的增高显著,骨吸收持续影响较大,骨代谢处于失偶联的状态。若早期能有效地控制骨吸收将有利于加强骨形成的能力,最终有利于缩短骨折愈合时间。

Objective To study the variation of bone metabolism in osteoporosis fracture patients in the course of fracture healing, and find a more effective therapy in clinic. Methods Observe the variation of the level of serum osteocalcin and urine deoxypyridinoline in 80 pathologic fracture patients in the course of fracture healing. Results The serum osteocalcin tends to increase after fracture and is likely to exceed the range of normal value, reaches the peak after three weeks and returns back to the normal range after six weeks; the urine deoxypyridinoline tends to increase after fracture beyond the range of normal value completely, reaches the peak after six weeks, falls to the normal range after nine weeks but cann＇t recover to the normal range completely. Conclusion The bone transition is very active in the early stage of the pathologic fracture. The level of serum osteocalcin and urine deoxypyridinoline all increase,especially of the serum osteocalcin. The bone absorption has more continuous effort and the bone metabolism is uncoupling. Controlling the bone absorption effectively in early stage will benefit to enhance the ability of bone formation and shorten the healing time finally.