阿托伐他汀对老年高脂血症妇女血脂和骨密度的影响

The effect of atorvastatin on hyperlipoidemia and bone density in old women

目的观察阿托伐他汀对老年高脂血症妇女血脂和骨密度的影响。方法66例老年高脂血症妇女随机分为观察组（n=34）和对照组（n=32）,观察组予阿托伐他汀10mgQ.N,对照组予非诺贝特100mgbid,共观察治疗40周,治疗前后分别测定血脂全套和骨密度（腰椎2-4、股骨颈和大粗隆和Wards区）和骨代谢指标血钙、磷、碱性磷酸酶、甲状旁腺素和降钙素。结果两组治疗后较治疗前总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL）均有降低且高密度脂蛋白胆固醇（HDL）升高（P〈0.05）,但观察组对TC、HDL、LDL的作用优于对照组（P〈0.05）。观察组腰椎2-4、股骨颈和大粗隆的骨密度参数值较治疗前和对照组均明显增高（P〈0.05）。骨代谢各指标治疗前后差异无显著性（P〉0.05）。结论阿托伐他汀和非诺贝特对老年高脂血症妇女均有良好的调脂作用,阿托伐他汀调脂作用优于非诺贝特;阿托伐他汀可增加老年高脂血症妇女的骨密度。

Objective To investigate the effect of atorvastatin on hyperlipoidemia and bone density in old women. Methods 66 old women with hyperlipoidemia were randomly classed into observation group（ n = 34） and control group（ n = 32）. Atorvastatin 10 mg p.o.Q. N in observation group and fenofibrate 100 mg p.o.B.i, d in control group. Phase of treatment lasted for 40 weeks. Serum lipid and bone density （ lumar vertebrae 2 - 4, proximal femur, including Neck, Troth, Ward＇s） were measured before treatment and after 40 weeks. Osteal-metabolize markers were tested at the same. Results Compared with pretherapy, serum total cholesterol（TC）, triglycerides （TG）, and low density lipoprotein cholesterol（LDL） were lower and high density lipoprotein cholesterol（HDL） was higher after treatment in both groups（ P 〈 0.05）. But atorvastatin was more significant than fenofibrate（ P 〈 0.05）. The parameter value of bone density at lumbar vertebrae 2 - 4 and proximal femur （neck and Troch） were significalntly increased in observation group compared with control group and pretherapy （ P 〈 0.05 ）. Osteal- metabolize markers were not changed in two groups in two groups after treatment （ P 〈 0.05 ）. Conclusion Both atorvastatin and fenoberate have satisfactory regulations on hyperlipoidemia in old women and atorvastatin has an advantage over febeberate. Atorvastatin may increased bone denstiy on old woman with hyperlipoidemia.