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肿瘤化学预防剂吲哚-3-甲醇作用的靶点 被引量：2

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摘要 从蔬菜水果中发现的抗肿瘤生物活性成分一直是研究的热点。本文对十字花科蔬菜活性成分吲哚-3-甲醇(indole-3-carbinol,I3C)的抗肿瘤活性进行综述,重点综述了吲哚-3-甲醇影响致癌物代谢、抗肿瘤细胞增殖、诱导细胞凋亡、诱导细胞周期阻滞、调节转录因子和基因表达等靶点的研究现状和进展。
作者 周颖 朱伟 杨杏芬
机构地区 广州市疾病预防控制中心 广东省疾病预防控制中心
出处 《热带医学杂志》 CAS 2007年第8期824-827,815,共5页 Journal of Tropical Medicine
基金 广东省教育厅自然科学基金(No.Z03020)
关键词 十字花科蔬菜 吲哚-3-甲醇 凋亡 细胞周期阻滞
分类号 R114 [医药卫生—卫生毒理学]
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参考文献31

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  • 2HOWELLS LM,GALLACHER-HORLEY B,HOUGHTON CE,et al.Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line[J].Mol Cancer Ther,2002,1:1161-1172.
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同被引文献19

  • 1Krzeslak A. Akt kinase: a key regulator of metabolism and progression of tumors[J]. Postepy Hig Med Dosw (Online), 2010, 64 : 490-503.
  • 2Dashwood RH.Indole-3-carbinol : anticarcinogen tumor promoter in brassica vegetables [J ] ? Chem Biol Interact, 1998, 110(1-2) : 1-5.
  • 3Safe S, Papineni S, Chintharlapalli S.Cancer ehemotherapy with indole-3-earbinol, bis (3'-indolyl) methane and synthetic analogs [ J ] .Cancer Lett, 2008,269 (2) : 326-338.
  • 4Sundar SN,Kerekatte V,Equinozio CN,et al.Indole-3-earbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells[J]. Mol Endocfinol, 2006, 20 ( 12 ) : 3070-3082.
  • 5Martelli AM,Faenza I,Billi AM,et al.Intranuclear 3'- phosphoinositide metabolism and Akt signaling:new mechanisms for tumorigenesis and protection against apoptosis [ J] ? Cell Signal, 2006,18(8) : 1101-1107.
  • 6Souli E,Machluf M,Morgenstern A,et al.Indole-3-earbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice [ J ]. Food Chem Toxieol, 2008,46 ( 3 ) : 863- 870.
  • 7Bradlow HL.Review.Indole-3-earbinol as a ehemoproteetive agent in breast and prostate cancer [ J ]. In Vivo, 2008,22 (4) : 441-445.
  • 8Higdon JV, Delage B, Williams DE, et al.Cruciferous vegetables and human cancer risk:epidemiologic evidence and mechanistic basis [ J ]. Pharmacol Res, 2007,55 ( 3 ) : 224-236.
  • 9Fulda S, Debatin KM. Apoptosis signaling in tumor therapy[J]. Ann N Y Acad Sci, 2004,1028 : 150-156.
  • 10赵华强,王东,李兵,许雅香,沈卫德.家蚕细胞色素P450基因CYP9A22的克隆及在中肠和脂肪体的诱导转录[J].蚕业科学,2008,34(4):634-641. 被引量：8

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热带医学杂志
2007年 第8期

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