一种新的脂肪细胞源性血管舒张因子

Adipocyte-derived relaxing factor,a new vasodilative factor

Although our knowledge of ADRF(adipocyte-derived relaxing factor) is extremely limited,the little that is known has already revealed a promising future in this newly found factor.Firstly,it is secreted by adipose tissue,which is a abundantly and extensively distributed in human body and has become a hot spot for research work in recent years.Secondly,ADRF has shown a significant vasodilative action in a considerable number of experiments conducted on arteries of various sizes,from different body parts of different species of animals,including human.In this article,we introduce the development of ADRF research,sum up its known properties,including its Ca2+,protein tyrosine kinase,and protein kinase A dependent releasing,K+ channel mediated functioning,and interfered effect in different pathological models,and propose problems surrounding this factor and directions for future research work.

Although our knowledge of ADRF （ adipocyte - derived relaxing factor） is extremely limited, the little that is known has already revealed a promising future in this newly found factor. Firstly, it is secreted by adipose tissue, which is a abundantly and extensively distributed in human body and has become a hot spot for research work in recent years. Secondly, ADRF has shown a significant vasodilative action in a considerable number of experiments conducted on arteries of various sizes, from different body parts of different species of animals, including human. In this article, we intreduce the development of ADRF research, sum up its known properties, including its Ca^2＋ , protein tyrosine kinase, and protein kinase A dependent releasing, K^＋ channel mediated functioning, and interfered effect in different pathological models, and propose problems surrounding this factor and directions for future research work.